ea0005oc34 | Thyroid and Calcium | BES2003
Martin N
, Small C
, Sajedi A
, Ghatei M
, Hochgeschwender U
, Bloom S
The generation of a knockout mouse lacking all POMC-derived peptides by Yaswen et al provided further support for the importance of the melanocortin system in regulating body weight. POMC-null mice have a greater food intake than wild-type littermates on both low fat and high fat diets, resulting in increased body weight. In addition to obesity, these mice have altered pigmentation and defective adrenal development.The hypothalamo-pituitary-thyroid axis (HPT) in the...